1、 Drug Impurity
We supply over 20000 types of spot impurity reference materials, with sufficient supply and same day delivery to meet customers' urgent needs for replenishment at any time. The company has its own research and development center and laboratory, and the team members have over ten years of experience in developing drug impurity reference standards. Our website www.molcoo.com covers over 98% of cutting-edge generic drug projects, with complete structural formulas that greatly save customers time in impurity structure analysis and inference. All products undergo strict quality control testing and provide relevant information such as COA, H-NMR, C-NMR, MS/GC-MS, HPLC/GC purity, QNMR quantification, TGA thermogravimetric analysis, IR infrared, UV ultraviolet, two-dimensional (COSY, NOESY, HMBC, HMQC), etc. These structural confirmation spectra ensure quality and reliability. Our products have a wide range of categories, fast delivery time, good quality, and low prices, which can quickly solve various customer needs such as replenishment and consistency evaluation.
2、 Customized synthesis of impurities and new molecules
1. CDE has sent out impurities for replenishment, and all brands have no stock available. Customized synthesis is required, and we can complete the project as quickly as possible and report the progress to the customer on a weekly basis.
2. For impurities with established quality standards, some brands are expensive, have delayed supply, unstable quality, and cannot sustain supply. After successful customized development by Moko, it can ensure stable supply and never exceed the previous purchase price.
3. For the customized synthesis of new compounds for innovative drug research and development companies, there are basically no literature reports on this type of compound. The Moko New Molecular Customized Synthesis team has strong new molecular synthesis capabilities.
3、 Drug standard
We provide one-stop purchasing services for official standard products such as CP, EP, USP, BP, JP, etc., helping customers purchase at import cost prices.
4、 Preparation and separation of unknown impurities
Considering that many impurities in projects cannot be obtained through synthetic methods and need to be obtained from trace target compounds contained in raw materials, intermediates, crude products of reactions, or side reactions, Hubei Moke has a professional impurity preparation and separation technology team equipped with professional SFC preparation and separation instruments, which can efficiently and accurately separate complex project impurities and solve impurity preparation problems for customers.
5、 Process development of new drug intermediates
We not only provide the supply of new drugs and molecular impurities, but also offer process optimization services. Such as the screening of commercial routes (small-scale research, pilot scale, workshop production), the development and optimization of commercial processes through reaction design (DoE) and quality design (QbD), unit operation research and confirmation of key process parameters at each step, structural identification and analysis of impurities, analysis of impurity sources and quality control research, development of various analytical methods, to assist customers in their new drug development journey.
6、 Drug peptide synthesis
In the process of peptide synthesis, some heteropeptides with similar structures to the target peptide are generated, such as diastereomers caused by amino acid racemization, missing peptides caused by partial unconnected amino acids, and broken peptides caused by peptide bond cleavage. Therefore, it is necessary to consider selecting reliable separation and purification methods to achieve the required purity of peptides. The sources of process impurities in synthetic peptide raw materials are different from those in general chemical drugs. Possible process impurities include: missing (incomplete) peptides, broken peptides, deamidated peptides, by-products formed by incomplete deprotection of amino acid side chains, oxidized peptides, disulfide bond exchange products, diastereomeric peptides, oligomers and/or polymers, as well as toxic reagents and solvents used in synthesis. In the research of substance inspection methods for synthetic peptide drugs, it is necessary to fully consider these possible process impurities, and the validation of the detection ability of these process impurities is an important aspect of methodological validation.
Moko has a professional team for drug peptide synthesis, which can customize the synthesis of drug peptides based on the peptide sequences provided by customers. We can also provide customers with various degradation impurities and process impurities generated during peptide drug research and development in stock. We provide routine structural diagnostic spectrum data such as mass spectrometry, liquid chromatography, and ultraviolet spectroscopy. We can also provide amino acid composition analysis, amino acid sequence determination, and other data according to customer needs. According to customer project requirements, the purity range is generally 90% -99%.
